Jen Fairlie


I am BBSRC-funded research assistant working on telomere dynamics in wild Soay sheep on St Kilda. We use blood samples collected across the lifetimes of individuals from the long-term study on St Kilda  to understand how genes, early environmental conditions, growth and reproductive effort impact on life-long changes in leukocyte (white blood cell) telomere length in a wild mammal. We also aim to test to what extent telomere length predicts lifespan and lifetime fitness under natural conditions, and how natural selection might maintain genetic variation in telomere length.

 

Publications (previously Jen Dorrens):

Fairlie, J., Holland, R., Pilkington, J. G., Pemberton, J. M., Harrington, L., & Nussey, D. H. (2016). Lifelong leukocyte telomere dynamics and survival in a free‐living mammal. Aging cell, on-line early.
 
Fairlie, J & Harrington,L (2015) Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation. DNA Repair, 25 : 54-59.

Tabosky MA, Sealy DA, Dorrens J, Tayade C, Betts DH, Harrington L. (2012) Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis. Cell Reports, 1:91-8.

Boyd M, Ross SC, Dorrens J, Fullerton NE, Tan KW, Zalutsky MR, Mairs RJ. (2006) Radiation induced biological bystander effect elicited in vitro by targeted radiopharmaceuticals labelled with α-, β- and auger electron emitting radionucleotides. J. Nucl. Med. 47:1007-1015.

Boyd M, Mairs RJ, Keith WN, Ross SC, Welsh p, Akabani G, Owens J, Vaidyanathan G, Carruthers R, Dorrens J, Zalutsky MR. (2004) An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promotors and radioastatine and harnessing radiation mediated bystander effects. J. Gene. Med. 6:937-47.

Dorrens J, Rennie MJ. Effects of ageing and human whole body and muscle protein turnover. (2003) Scand. J. Med. Sci. Sports, 13:26-33.